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If yes, and cardiovascular disease is present Injectable GLP-1 with proven MACE reduction (liraglutide, dulaglutide, or injectable semaglutide) is preferred over Rybelsus If yes, and A1C is above 9.0% Injectable GLP-1 at higher doses will likely provide greater A1C reduction than Rybelsus 14 mg If no, due to needle phobia or refusal Continue to next question Can the patient reliably follow the empty-stomach dosing protocol
GLP-1 may regulate not only homeostatic thirst, but might also have a role in hedonic control and the pathophysiology of addiction (25, 26)
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PRODUCED VIA FERMENTATION, NOT SYNTHESIS: Setria is manufactured through a proprietary natural fermentation process at Kyowa Hakko's facilities not chemically synthesized
